Thanks to modern software, particularly face replacement, you can put any likeness, real or fictional, onto any actor. This is usually used as a toy on social media. But, it has much more potential, and it might kill off the very idea of movie stars altogether.
What a production can do now is to create a completely artificial face out of thin air, and paste that onto an actor in post. This means that you don't have to worry about actors calling in sick, or taking maternity leave. You just replace them with someone else, and it won't matter, because you're going to replace their faces anyway. And you could conceivably keep a franchise going indefinitely. In fact, don't be surprised if a new Star Trek or Star Wars film will be made one day using facial skins from the original cast when they were young. Not that Star Wars will live much longer, it seems, but you never know.
Of course there is the issue of body language and mannerisms, but I'm not sure how that will affect the final product. But this scenario I've laid out is not doubt going through the heads of a lot of production companies.
In fact I'd go further and say that many films will be literally 100% CGI. Of course actual people will have to be used for motion capture, but you'll see absolutely no photography on the screen. Don't believe me? Look at the latest version of Flight Simulator. A lot of commercial photography is being replaced by CGI already. That's probably a sign of things to come.