I'm finding CS 6 to be fairly buggy. Premier has weird audio issues. I'm getting no sound out in many sequences despite levels being displayed. I can take an HD Sequence that is having this issue, copy and paste the timeline into a 5k sequence and suddenly the audio works. Have tried numerous outputs, system and Decklink.
Photoshop is even worse. It seems to have poor integration with my Wacom tablet and crashes on occasion. I did a fresh install of Lion on a separate SSD drive before installing CS 6. Fortunately I still have my previous system drive connected and can just switch back to CS 5.5 with a restart. Photoshop CS 5.5 has never ever crashed on my system and my still images are often about 2GB in size.
What up, Adobe? There's a lot I like in CS 6, fix that bad boy!